Today the World Health Organization rarely comes close to achieving its targets in combating disease. Its target-setting mechanisms have been so misused that WHO has lost credibility. WHO targets have been unrealistic or impossible to measure, leading some to conclude that they are designed primarily—if not entirely—for fundraising, cheerleading, and motivational purposes. Worse still, WHO’s approach is being copied by other United Nations agencies. WHO should drop its grandiose goals in favor of measured and sustainable approaches to disease control that yield results.